Article

Antimicrobial overproduction sustains intestinal inflammation by inhibiting <i>Enterococcus</i> colonization

2023-01-31

Abstract excerpt

<h4>SUMMARY</h4> Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiota. Patients with inflammatory bowel disease (IBD) experiencing flares displayed heightened levels of secreted REG3 proteins that mediated depletion of Ente...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3d98105-d2e3-5b96-a2bc-1c2f0b146af7
DOI: 10.1101/2023.01.29.526128

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antimicrobial overproduction sustains intestinal inflammation by inhibiting <i>Enterococcus</i> colonizationDOI 10.1101/2023.01.29.526128Read

Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2Semantic proximity Read

Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut MicrobiotaSemantic proximity Read

Regnase-1 deficiency restrains <i>Klebsiella pneumoniae</i> infection by regulation of a Type I interferon responseSemantic proximity Read

Commensal and Probiotic Bacteria Influence Intestinal Barrier Function and Susceptibility to Colitis in Nod1−/−;Nod2−/− MiceSemantic proximity Read

Inflammatory bactericidal lectin RegIIIβ: Friend or foe for the host?Semantic proximity Read

Nod2: a key regulator linking microbiota to intestinal mucosal immunity.Semantic proximity Read

Inducible, but not constitutive, pancreatic <i>REG/Reg</i> isoforms are regulated by intestinal microbiota and pancreatic diseasesSemantic proximity Read

Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitisSemantic proximity Read

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22–mediated containment of commensal microbiotaSemantic proximity Read

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancerSemantic proximity Read

Pathogenic mechanisms underlying immune dysregulation associated to hypomorphic Rag2 mutation : role of microbiota at mucosal interfacesSemantic proximity Read

The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell-Induced Enteropathy.Semantic proximity Read