Article
Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia.
Molecular psychiatry - 1 Jan 2023
Wen Jia, Trost Brett, Engchuan Worrawat, Halvorsen Matthew, Pallotto Linda M, Mitina Aleksandra, Ancalade NaEshia, Farrell Martilias, Backstrom Ian, Guo Keyi, Pellecchia Giovanna, Thiruvahindrapuram Bhooma, Giusti-Rodriguez Paola, Rosen Jonathan David, Li Yun, Won Hyejung, Magnusson Patrik K E, Gyllensten Ulf, Bassett Anne S, Hultman Christina M, Sullivan Patrick F, Yuen Ryan K C, Szatkiewicz Jin P
Abstract excerpt
Tandem repeat expansions (TREs) are associated with over 60 monogenic disorders and have recently been implicated in complex disorders such as cancer and autism spectrum disorder. The role of TREs in schizophrenia is now emerging. In this study, we have performed a genome-wide investigation of TREs in schizophrenia. Using genome sequence data from 1154 Swedish schizophrenia cases and 934 ancestry-matched...
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