Article
Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution.
Molecular psychiatry - 1 Jan 2022
Xiao Xiao, Zhang Chu-Yi, Zhang Zhuohua, Hu Zhonghua, Li Ming, Li Tao
Abstract excerpt
Genome-wide association studies (GWASs) have revealed substantial genetic components comprised of single nucleotide polymorphisms (SNPs) in the heritable risk of psychiatric disorders. However, genetic risk factors not covered by GWAS also play pivotal roles in these illnesses. Tandem repeats, which are likely functional but frequently overlooked by GWAS, may account for an important proportion in the "missing...
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