Article
Genome-wide tandem repeat expansions contribute to schizophrenia risk.
Molecular psychiatry - 1 Sept 2022
Mojarad Bahareh A, Engchuan Worrawat, Trost Brett, Backstrom Ian, Yin Yue, Thiruvahindrapuram Bhooma, Pallotto Linda, Mitina Aleksandra, Khan Mahreen, Pellecchia Giovanna, Haque Bushra, Guo Keyi, Heung Tracy, Costain Gregory, Scherer Stephen W, Marshall Christian R, Pearson Christopher E, Bassett Anne S, Yuen Ryan K C
Abstract excerpt
Tandem repeat expansions (TREs) can cause neurological diseases but their impact in schizophrenia is unclear. Here we analyzed genome sequences of adults with schizophrenia and found that they have a higher burden of TREs that are near exons and rare in the general population, compared with non-psychiatric controls. These TREs are disproportionately found at loci known to be associated with schizophrenia from...
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