Article
Treatment patterns and outcomes in metastatic castration-resistant prostate cancer patients with and without somatic or germline alterations in homologous recombination repair genes.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2024
Olmos D, Lorente D, Alameda D, Cattrini C, Romero-Laorden N, Lozano R, Lopez-Casas P P, Jambrina A, Capone C, Vanden Broecke A M, Trevisan M, Van Sanden S, Jürgens A, Herrera-Imbroda B, Castro E
Abstract excerpt
BACKGROUND: Although germline BRCA mutations have been associated with adverse outcomes in prostate cancer (PC), understanding of the association between somatic/germline alterations in homologous recombination repair (HRR) genes and treatment outcomes in metastatic castration-resistant PC (mCRPC) is limited. The aim of this study was to investigate the prevalence and outcomes associated with somatic/germline HRR...
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