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Article

Impact of homologous recombination repair gene mutations on survival in metastatic prostate cancer: A real-world analysis from an observational database.

The French journal of urology - 1 Aug 2026

Cancel-Tassin Géraldine, Kariyawasam Thilina, Gautier Laurène, Lefèvre Lucile, Cussenot Olivier

Abstract excerpt

The prognostic significance of homologous recombination repair gene (HRRg) mutations across the different metastatic prostate cancer stages remains unclear. This retrospective real-world study analyzed 162 metastatic castration-sensitive (mCSPC) and 126 castration-resistant (mCRPC) patients from the ProGène database, stratified by HRRg mutational status. Mutation prevalence was similar in both groups (16.0% in...

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Identifiers

PMID: 42263912
DOI: 10.1016/j.fjurol.2026.103143

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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