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Article

Prevalence of homologous recombination repair genes alterations in metastatic castration-resistant prostate cancer, a multicentric study.

The French journal of urology - 1 Aug 2026

Allaume Pierre, Raby Maxime, Nourieh Maya, Lespagnol Alexandra, Tallet Anne, Péricart Sarah, Tantot Juliet, Lindner Véronique, Decaussin Myriam, Callens Céline, Descotes Françoise, Allory Yves, Rioux-Leclercq Nathalie, Kammerer-Jacquet Solène-Florence, Fromont Gaëlle

Abstract excerpt

INTRODUCTION: Homologous Recombination Repair (HRR) genes alterations are a resistance mechanism to therapies by taxanes or Androgen Receptor Signalling inhibitors in Metastatic Castration Resistant Prostate Cancer (mCRPC). BRCA-mutated mCRPC patients are eligible to poly adenosine diphosphateribose polymerase inhibitors (PARPi). Therefore, assessing the population-specific prevalence of HRR-related genes...

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Identifiers

PMID: 42303208
DOI: 10.1016/j.fjurol.2026.103148

Genes

BRCA1
ATM
BRCA2
CDK12
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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