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Article

A novel NGS-based microsatellite instability (MSI) status classifier with 9 loci for colorectal cancer patients.

Journal of translational medicine - 28 May 2020

Zheng Kai, Wan Hua, Zhang Jie, Shan Guangyu, Chai Ningning, Li Dongdong, Fang Nan, Liu Lina, Zhang Jingbo, Du Rong, Wu Qixi, Li Xichuan, Zhang Chunze

Abstract excerpt

BACKGROUND: With the recent emergence of immune checkpoint inhibitors, microsatellite instability (MSI) status has become an important biomarker for immune checkpoint blockade therapy. There are growing technical demands for the integration of different genomic alterations profiling including MSI analysis in a single assay for full use of the limited tissues. METHODS: Tumor and paired control samples from 64...

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Biomarkers, Tumor
Colorectal Neoplasms
DNA Mismatch Repair
Genetic factors in colorectal cancer
Microsatellite Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32466784
DOI: 10.1186/s12967-020-02373-1
PMCID: PMC7257555

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