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Mitochondrial haplogroups and cognitive progression in Parkinson’s disease

7 Sept 2022

Abstract excerpt

Mitochondria are a culprit in the onset of Parkinson's disease, but their role during disease progression is unclear. Here we used Cox proportional hazards models to exam the effect of variation in the mitochondrial genome on longitudinal cognitive and motor progression over time in 4064 patients with Parkinson's disease. Mitochondrial macro-haplogroup was associated with reduced risk of cognitive disease...

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PMID: 36343661
DOI: 10.1093/brain/awac327

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