Article
Detection of CEBPA double mutants in acute myeloid leukemia using a custom gene expression array.
Genetic testing and molecular biomarkers - 1 May 2013
van Vliet Martin H, Burgmer Pia, de Quartel Linda, Brand Jaap P L, de Best Leonie C M, Viëtor Henk, Löwenberg Bob, Valk Peter J M, van Beers Erik H
Abstract excerpt
Double (bi-allelic) mutations in the gene encoding the CCAAT/enhancer-binding protein-alpha (CEBPA) transcription factor have a favorable prognostic impact in acute myeloid leukemia (AML). Double mutations in CEBPA can be detected using various techniques, but it is a notoriously difficult gene to sequence due to its high GC-content. Here we developed a two-step gene expression classifier for accurate and...
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