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A Sporozoite Asparagine-Rich Protein Controls Initiation of Plasmodium Liver Stage Development

12 Jun 2008

Abstract excerpt

Plasmodium sporozoites invade host hepatocytes and develop as liver stages (LS) before the onset of erythrocytic infection and malaria symptoms. LS are clinically silent, and constitute ideal targets for causal prophylactic drugs and vaccines. The molecular and cellular mechanisms underlying LS development remain poorly characterized. Here we describe a conserved Plasmodium asparagine-rich protein that is...

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PMID: 18551171
DOI: 10.1371/journal.ppat.1000086

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