Protracted Sterile Protection with<i>Plasmodium yoelii</i>Pre‐erythrocytic Genetically Attenuated Parasite Malaria Vaccines Is Independent of Significant Liver‐Stage Persistence and Is Mediated by CD8⁺T Cells

Abstract excerpt

Irradiation-attenuated sporozoite vaccinations confer sterile protection against malaria infection in animal models and humans. Persistent, nonreplicating parasite forms in the liver are presumably necessary for the maintenance of sterile immunity. A novel vaccine approach uses genetically attenuated parasites (GAPs) that undergo arrested development during liver infection. The fate of GAPs after immunization,...

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