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The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians.

Nature communications - 4 Nov 2022

Kim Young Jin, Moon Sanghoon, Hwang Mi Yeong, Han Sohee, Jang Hye-Mi, Kong Jinhwa, Shin Dong Mun, Yoon Kyungheon, Kim Sung Min, Lee Jong-Eun, Mahajan Anubha, Park Hyun-Young, McCarthy Mark I, Cho Yoon Shin, Kim Bong-Jo

Abstract excerpt

Metabolic traits are heritable phenotypes widely-used in assessing the risk of various diseases. We conduct a genome-wide association analysis (GWAS) of nine metabolic traits (including glycemic, lipid, liver enzyme levels) in 125,872 Korean subjects genotyped with the Korea Biobank Array. Following meta-analysis with GWAS from Biobank Japan identify 144 novel signals (MAF ≥ 1%), of which 57.0% are replicated in...

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Identifiers

PMID: 36333282
DOI: 10.1038/s41467-022-34163-2
PMCID: PMC9636136

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