Article
Clinical and molecular characteristics of kinase domain duplications across diverse cancer types in the Chinese population.
Cancer medicine - 1 Mar 2023
Lai Xiaojing, Yu Ruoying, Ou Qiuxiang, Bao Hua, Wu Xue, Shao Yang, Li Yang, Zhang Ying, Ding Qingqing
Abstract excerpt
BACKGROUND: Kinase domain duplications (KDDs) have recently been recognized as oncogenic mutations and possible association with drug resistance in cancers. METHOD: Here, targeted sequencing was performed with the tumor tissue and/or plasma from 65 cancer patients with KDDs. RESULT: Intact KDDs were identified in approximately 0.1% of the total population across multiple cancer types. EGFR KDD was first...
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