Article
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine.
Cell host & microbe - 14 Dec 2022
Wu Yangtao, Wang Shaojuan, Zhang Yali, Yuan Lunzhi, Zheng Qingbing, Wei Min, Shi Yang, Wang Zikang, Ma Jian, Wang Kai, Nie Meifeng, Xiao Jin, Huang Zehong, Chen Peiwen, Guo Huilin, Lan Miaolin, Xu Jingjing, Hou Wangheng, Hong Yunda, Chen Dabing, Sun Hui, Xiong Hualong, Zhou Ming, Liu Che, Guo Wenjie, Guo Huiyu, Gao Jiahua, Gan Congling, Li Zhixiong, Zhang Haitao, Wang Xinrui, Li Shaowei, Cheng Tong, Zhao Qinjian, Chen Yixin, Wu Ting, Zhang Tianying, Zhang Jun, Cao Hua, Zhu Huachen, Yuan Quan, Guan Yi, Xia Ningshao
Abstract excerpt
SARS-CoV-2 spread in humans results in continuous emergence of new variants, highlighting the need for vaccines with broad-spectrum antigenic coverage. Using inter-lineage chimera and mutation-patch strategies, we engineered a recombinant monomeric spike variant (STFK1628x) that contains key regions and residues across multiple SAR-CoV-2 variants. STFK1628x demonstrated high immunogenicity and mutually...
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