Article

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

2022-01-26

Abstract excerpt

The widespread SARS-CoV-2 in humans results in the continuous emergence of new variants. Recently emerged Omicron variant with multiple spike mutations sharply increases the risk of breakthrough infection or reinfection, highlighting the urgent need for new vaccines with broad-spectrum antigenic coverage. Using inter-lineage chimera and mutation patch strategies, we engineered a recombinant monomeric spike variant...

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Literature Corpus work: 1d6faf67-1398-553a-bc5f-ac73e6d9208e
DOI: 10.1101/2022.01.25.477789

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