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Article

Universal subunit vaccine protects against multiple SARS-CoV-2 variants and SARS-CoV

25 Jul 2024

Abstract excerpt

Although Omicron RBD of SARS-CoV-2 accumulates many mutations, the backbone region (truncated RBD) of spike protein is highly conserved. Here, we designed several subunit vaccines by keeping the conserved spike backbone region of SARS-CoV-2 Omicron BA.1 subvariant (S-6P-no-RBD), or inserting the RBD of Delta variant (S-6P-Delta-RBD), Omicron (BA.5) variant (S-6P-BA5-RBD), or ancestral SARS-CoV-2 (S-6P-WT-RBD) to...

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PMID: 39054338
DOI: 10.1038/s41541-024-00922-z

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