Article
A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice.
Frontiers in cellular and infection microbiology - 1 Jan 2025
Chen Xianying, Zhang Yuzhen, Yang Shimin, Chen Yan, Qian Shengnan, Zhang Zhen, Liu Qianyun, Ma Chengbao, Yu Weiyi, Feng Jiangpeng, Liu Jiejie, Guo Ming, Huang Zhixiang, Wang Xin, Chen Jie, Zhao Haiyan, Yan Huan, Lan Ke, Chen Yu, Zhou Li
Abstract excerpt
Introduction: The emergence of new SARS-CoV-2 variants with immune evasion capabilities underscores the importance of developing a broad-spectrum and effective vaccine. The receptor binding domain (RBD) of the Spike protein has been widely utilized in vaccine due to its high immunogenicity. However, the Spike protein, particularly the RBD region, exhibits significant variability in the evolution of SARS-CoV-2,...
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