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Article

Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure.

Antimicrobial agents and chemotherapy - 20 Dec 2022

Bonnet Pierre L, Le Gal Solène, Gautier Chloé, Hoffmann Claire V, Le Nan Nathan, Happe André, Le Berre Rozenn, Saraux Alain, Nevez Gilles

Abstract excerpt

Pneumocystis jirovecii infections occur in patients treated with methotrexate (MTX) because of immunosuppressive effects of this highly potent dihydrofolate reductase (DHFR) inhibitor. Conversely, MTX may act as an anti-P. jirovecii drug and consequently may exert a selective pressure on this fungus. In this context, we compared the sequences of the dhfr gene of P. jirovecii isolates obtained from two groups of...

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Identifiers

PMID: 36317930
DOI: 10.1128/aac.00990-22
PMCID: PMC9765006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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