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Article

Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis.

Antimicrobial agents and chemotherapy - 1 Nov 2004

Nahimana Aimable, Rabodonirina Meja, Bille Jacques, Francioli Patrick, Hauser Philippe M

Abstract excerpt

Most drugs used for prevention and treatment of Pneumocystis jirovecii pneumonia target enzymes involved in the biosynthesis of folic acid, i.e., dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR). Emergence of P. jirovecii drug resistance has been suggested by the association between failure of prophylaxis with sulfa drugs and mutations in DHPS. However, data on the occurrence of mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Open in PubMed Open full text

Identifiers

PMID: 15504856
DOI: 10.1128/AAC.48.11.4301-4305.2004
PMCID: PMC525445

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis.PMID 15504856Read ↗

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