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Article

Molecular detection of DHFR gene polymorphisms in Pneumocystis jirovecii isolates from Indian patients.

Journal of infection in developing countries - 30 Nov 2015

Singh Yogita, Mirdha Bijay Ranjan, Guleria Randeep, Khalil Shehla, Panda Ashutosh, Chaudhry Rama, Mohan Anant, Kabra Sushil Kumar, Kumar Lalit, Agarwal Sanjay Kumar

Abstract excerpt

INTRODUCTION: Pneumocystis pneumonia (PCP) is an opportunistic life-threatening infection, especially for immunocompromised individuals. A trimethoprim-sulfamethoxazole (TMP-SMX) combination is commonly used for the treatment of PCP, targeting both dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes. Several studies have already shown that polymorphisms in the DHPS gene are associated with...

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Source

Identifiers

PMID: 26623634
DOI: 10.3855/jidc.6810

Genes

DHFR
DHPS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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