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Article

Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort.

Infection - 1 Jun 2017

Suárez Isabelle, Roderus Lisa, van Gumpel Edeltraud, Jung Norma, Lehmann Clara, Fätkenheuer Gerd, Hartmann Pia, Plum Georg, Rybniker Jan

Abstract excerpt

BACKGROUND: Pneumocystis pneumonia (PCP) is an opportunistic and potentially life-threatening infection of immunocompromised individuals. A combination of trimethoprim-sulfamethoxazole is widely used for prophylaxis and treatment of PCP. Polymorphisms in the drug targets, the dihydropteroate synthase (DHPS) or the dihydrofolate reductase (DHFR) are presumably a reason for treatment failure. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28303545
DOI: 10.1007/s15010-017-1005-4

Genes

DHPS
DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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