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Article

Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice.

Translational psychiatry - 31 Oct 2022

He Lujuan, Zheng Yi, Huang Lixuan, Ye Jingyi, Ye Yinyi, Luo Hanyue, Chen Xi, Yao Wei, Chen Jiaxu, Zhang Ji-Chun

Abstract excerpt

The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice. However, the key molecular mechanism that mediates major depressive disorder (MDD) pathogenesis remains elusive. We herein show that Nrf2 regulates TREM2 transcription and effects TREM2 mRNA and protein expression. The activation of Nrf2...

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Identifiers

PMID: 36316319
DOI: 10.1038/s41398-022-02227-y
PMCID: PMC9622811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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