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Article

Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 May 2023

Zhang Jinqiang, Li Liangyuan, Liu Qin, Zhao Zhihuang, Su Dapeng, Xiao Chenghong, Jin Ting, Chen Li, Xu Chunyun, You Zili, Zhou Tao

Abstract excerpt

BACKGROUND: Regulating the microglial phenotype is an attractive strategy for treating diseases of the central nervous system such as depression and anxiety. Gastrodin can quickly cross the blood-brain barrier and mitigate microglia-mediated inflammation, which widely used to treat a variety of central nervous system diseases associated with microglial dysfunction. However, the molecular mechanism by which...

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PMID: 36867963
DOI: 10.1016/j.phymed.2023.154725

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