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Article

GSP1-111 Modulates the Microglial M1/M2 Phenotype by Inhibition of Toll-like Receptor 2: A Potential Therapeutic Strategy for Depression.

International journal of molecular sciences - 1 Oct 2024

Kim Ryeong-Eun, Mabunga Darine Froy, Boo Kyung-Jun, Kim Dong Hyun, Han Seol-Heui, Shin Chan Young, Kwon Kyoung Ja

Abstract excerpt

Neuroinflammation plays a vital role in neurodegenerative diseases and neuropsychiatric disorders, and microglia and astrocytes chiefly modulate inflammatory responses in the central nervous system (CNS). Toll-like receptors (TLRs), which are expressed in neurons, astrocytes, and microglia in the CNS, are critical for innate immune responses; microglial TLRs can regulate the activity of these cells, inducing...

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Identifiers

PMID: 39408923
DOI: 10.3390/ijms251910594
PMCID: PMC11476561

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