CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness.

doi:10.1073/pnas.1911816117

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Article

CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2020

Lago Natalia, Kaufmann Fernanda N, Negro-Demontel María Luciana, Alí-Ruiz Daniela, Ghisleni Gabriele, Rego Natalia, Arcas-García Andrea, Vitureira Nathalia, Jansen Karen, Souza Luciano M, Silva Ricardo A, Lara Diogo R, Pannunzio Bruno, Abin-Carriquiry Juan Andrés, Amo-Aparicio Jesús, Martin-Otal Celia, Naya Hugo, McGavern Dorian B, Sayós Joan, López-Vales Rubèn, Kaster Manuella P, Peluffo Hugo

Abstract excerpt

A role for microglia in neuropsychiatric diseases, including major depressive disorder (MDD), has been postulated. Regulation of microglial phenotype by immune receptors has become a central topic in many neurological conditions. We explored preclinical and clinical evidence for the role of the CD300f immune receptor in the fine regulation of microglial phenotype and its contribution to MDD. We found that a...

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Identifiers

PMID: 32152116
DOI: 10.1073/pnas.1911816117
PMCID: PMC7104369

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