Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice.

Brain, behavior, and immunity - 1 Nov 2017

Zhang Jinqiang, Xie Xiaofang, Tang Mingming, Zhang Jing, Zhang Boyang, Zhao Qiuying, Han Yue, Yan Wan, Peng Cheng, You Zili

Abstract excerpt

Although accumulating evidence suggests that activated microglia are associated with deficits in neurogenesis and contribute to the physiopathology of major depressive disorder, the role of microglia in treating depression remains poorly understood. Our previous study showed that salvianolic acid (SalB) has the regulation of neuroinflammatory responses and antidepressant-like effects. Here, we hypothesized that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzofurans
Share to Cerebral Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depression

Share to Depressive Disorder

Share to Inflammation Mediators

Share to Microglia

Share to Neurogenesis

Share to Stress, Psychological

Source

Identifiers

PMID: 28736034
DOI: 10.1016/j.bbi.2017.07.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice.PMID 28736034Read ↗

Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2-Signal Transducer and Activator of Transcription 6 Pathway.Semantic proximity Read ↗

Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior.Semantic proximity Read ↗

Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway.Semantic proximity Read ↗

Modulating the polarization phenotype of microglia - A valuable strategy for central nervous system diseases.Semantic proximity Read ↗

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative DiseasesSemantic proximity Read ↗

Microglia as therapeutic target in central nervous system disorders.Semantic proximity Read ↗

IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice.Semantic proximity Read ↗

Electroacupuncture reprograms microglia to drive BDNF-dependent hippocampal neurogenesis and antidepressant responses in chronic stress modelSemantic proximity Read ↗

Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice.Semantic proximity Read ↗

Antidepressant therapies inhibit inflammation and microglial M1-polarization.Semantic proximity Read ↗

Heterogeneity of Microglia Phenotypes: Developmental, Functional and Some Therapeutic ConsiderationsSemantic proximity Read ↗

GSP1-111 Modulates the Microglial M1/M2 Phenotype by Inhibition of Toll-like Receptor 2: A Potential Therapeutic Strategy for Depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.