The CCL2 rs4586 SNP Is Associated with Slower Amyloid-β Deposition and Faster Tau Accumulation of Alzheimer's Disease.

doi:10.3233/JAD-220716

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Article

The CCL2 rs4586 SNP Is Associated with Slower Amyloid-β Deposition and Faster Tau Accumulation of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Gao Fan, Zhang Peng-Fei, Gao Jing, Song Jinghui, Chi Song

Abstract excerpt

BACKGROUND: CC-chemokine ligand 2 (CCL2), the key immunomodulatory chemokine for microglial activation, has been implicated in the pathogenesis of Alzheimer's disease (AD). Whether the association of CCL2 single nucleotide polymorphisms (SNPs) and the risk of AD is still controversial. OBJECTIVE: We aimed to investigate whether CCL2 rs4586 SNP is associated with the pathological changes and cognitive decline of...

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PMID: 36314210
DOI: 10.3233/JAD-220716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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