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Article

CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy.

Frontiers in immunology - 1 Jan 2020

Joly-Amado Aurelie, Hunter Jordan, Quadri Zainuddin, Zamudio Frank, Rocha-Rangel Patricia V, Chan Deanna, Kesarwani Anisha, Nash Kevin, Lee Daniel C, Morgan Dave, Gordon Marcia N, Selenica Maj-Linda B

Abstract excerpt

Innate immune activation is a major contributor to Alzheimer's Disease (AD) pathophysiology, although the mechanisms involved are poorly understood. Chemokine C-C motif ligand (CCL) 2 is produced by neurons and glial cells and is upregulated in the AD brain. Transgene expression of CCL2 in mouse models of amyloidosis produces microglia-induced amyloid β oligomerization, a strong indication of the role of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32508844
DOI: 10.3389/fimmu.2020.00997
PMCID: PMC7251073

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