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Article

Effect of regulating macrophage polarization phenotype on intervertebral disc degeneration.

Immunity, inflammation and disease - 1 Nov 2022

Hou Xuefeng, Shen Yucheng, Sun Minli, Zhang Bing, Dai Jiuming, Chen Dong, Liu Zhidong

Abstract excerpt

BACKGROUND: Macrophages are the only inflammatory cells that can penetrate the closed nucleus pulposus and their polarization plays an important role in intervertebral disc degeneration (IVDD). This paper attempted to investigate the pathogenesis of IVDD by altering the polarization state of macrophages. METHODS: Macrophage RAW264.7 cells were induced by interferonγ (IFN-γ) and lipopolysaccharide (LPS). The...

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Identifiers

PMID: 36301028
DOI: 10.1002/iid3.714
PMCID: PMC9609449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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