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Article

Bone marrow mesenchymal stem cells-derived exosomes repair degenerative intervertebral discs by modulating macrophage M1/M2 phenotype.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Feb 2026

Liang J, Mao J, Tan Z, Li J

Abstract excerpt

The effect of bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) on intervertebral disc degeneration (IVDD) repair and healing and its possible mechanism were investigated. Tail IVDD puncture was performed on mice, and BMSC-Exos were injected into the joint cavity. The disc morphology was observed by HE staining, apoptosis rate of nucleus pulposus (NP) tissues was determined by TUNEL, and polarization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41931734
DOI: 10.26402/jpp.2026.1.06

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CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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