Article
The JAK2 46/1 haplotype in Budd-Chiari syndrome and portal vein thrombosis.
Blood - 14 Apr 2011
Smalberg Jasper H, Koehler Edith, Darwish Murad Sarwa, Plessier Aurelie, Seijo Susana, Trebicka Jonel, Primignani Massimo, de Maat Moniek P M, Garcia-Pagan Juan-Carlos, Valla Dominique C, Janssen Harry L A, Leebeek Frank W G
Abstract excerpt
The germline JAK2 46/1 haplotype has been associated with the development of JAK2(V617F)-positive as well as JAK2(V617F)-negative myeloproliferative neoplasms (MPNs). In this study we examined the role of the 46/1 haplotype in the etiology and clinical presentation of patients with splanchnic vein thrombosis (SVT), in which MPNs are the most prominent underlying etiological factor. The single-nucleotide...
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