Article
Evaluation of the association between the JAK2 46/1 haplotype and chronic myeloproliferative neoplasms in a Brazilian population.
Clinics (Sao Paulo, Brazil) - 1 Jan 2013
Pagliarini-e-Silva Sarah, Santos Bruna Cunha, Pereira Elizangela Mendes de Figueiredo, Ferreira Mari Ellen, Baraldi Elaine Cristina, Sell Ana Maria, Visentainer Jeane Eliete Laguila
Abstract excerpt
OBJECTIVE: The JAK2 46/1 haplotype has recently been described as a major contributing factor to the development of myeloproliferative neoplasm, whether positive or negative forthe JAK2 V617F mutation. The G allele, identified by a single-nucleotide polymorphism known as JAK2 rs10974944, is part of the JAK2 46/1 haplotype. The aim of this study was to verify the association between the presence of the G allele...
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