Article

Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response

2022-07-25

Abstract excerpt

<h4>Rationale</h4> Rapid reperfusion is the most effective treatment for attenuating cardiac injury caused by myocardial ischemia. Yet, reperfusion itself elicits damage to the myocardium through incompletely understood mechanisms, known as ischemia/reperfusion (I/R) injury. The myocardium adapts to I/R by changes in gene expression, which determines the cellular response to reperfusion. Protein translation is a...

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Literature Corpus work: 5ea1fe2b-6259-5790-ac46-41d13e198be4
DOI: 10.1101/2022.07.25.501397

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