Article

BAM15 treats mouse sepsis and sepsis-AKI, linking circulating mitochondrial DNA and tubule reactive oxygen species

2021-07-07

Abstract excerpt

The pathogenesis of sepsis is complex and heterogeneous; hence, a precision medicine strategy may be required. Acute kidney injury (AKI) following sepsis portends higher mortality. Overproduction of mitochondrial reactive oxygen species (mtROS) is a potential mediator of sepsis and sepsis-induced AKI. BAM15 is a chemical uncoupler that dissipates the mitochondrial proton gradient without generating mtROS, and impr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b47c0fc-b586-52b8-9732-f68463d86307
DOI: 10.1101/2021.07.06.451287

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BAM15 treats mouse sepsis and sepsis-AKI, linking circulating mitochondrial DNA and tubule reactive oxygen speciesDOI 10.1101/2021.07.06.451287Read

Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injurySemantic proximity Read

Urinary Mitochondrial DNA Identifies Renal Dysfunction and Mitochondrial Damage in Sepsis‐Induced Acute Kidney InjurySemantic proximity Read

Renoprotective Effects of Montelukast in Sepsis-Induced AKI: Targeting the NF-κB PathwaySemantic proximity Read

Renoprotective Effects of Montelukast in Sepsis-Induced AKI: Targeting the NF-κB PathwaySemantic proximity Read

Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injurySemantic proximity Read

Mouse Models of SepsisSemantic proximity Read

Harnessing mitochondrial biogenesis to combat acute kidney injury: Current insights and futuredirectionsSemantic proximity Read

Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury.Semantic proximity Read

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse SepsisSemantic proximity Read

Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b <sup>+</sup> Leukocytes from Patients with SepsisSemantic proximity Read

Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylationSemantic proximity Read

Mitochondrial DNA in SepsisSemantic proximity Read