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Biophysical insights into glucose-dependent transcriptional regulation by PDX1

19 Oct 2022

Abstract excerpt

The pancreatic and duodenal homeobox 1 (PDX1) is a central regulator of glucose-dependent transcription of insulin in pancreatic β cells. PDX1 transcription factor activity is integral to the development and sustained health of the pancreas; accordingly, deciphering the complex network of cellular cues that lead to PDX1 activation or inactivation is an important step toward understanding the etiopathologies of...

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PMID: 36272648
DOI: 10.1016/j.jbc.2022.102623

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