Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes

9 Jun 2024

Abstract excerpt

Monogenic diabetes is a gateway to precision medicine through molecular mechanistic insight. Hepatocyte nuclear factor 1A (HNF-1A) and HNF-4A are transcription factors that engage in crossregulatory gene transcription networks to maintain glucose-stimulated insulin secretion in pancreatic β cells. Variants in the HNF1A and HNF4A genes are associated with maturity-onset diabetes of the young (MODY). Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38855865
DOI: 10.1172/jci.insight.175278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetesPMID 38855865Read ↗

Structural and biophysical characterization of HNF-1A as a tool to study MODY3 diabetes variantsSemantic proximity Read ↗

Functional characterization of HNF4A gene variants identify promoter and cell line specific transactivation effects.Semantic proximity Read ↗

Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants.Semantic proximity Read ↗

HNF-4alpha: from MODY to late-onset type 2 diabetes.Semantic proximity Read ↗

Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population.Semantic proximity Read ↗

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetesSemantic proximity Read ↗

Functional Analyses of HNF1A-MODY Variants Refine the Interpretation of Identified Sequence Variants.Semantic proximity Read ↗

Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of multiple cardiovascular disease risk factorsSemantic proximity Read ↗

HNF1A：From Monogenic Diabetes to Type 2 Diabetes and Gestational Diabetes Mellitus.Semantic proximity Read ↗

Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).Semantic proximity Read ↗

HNF1B-MODY in the Norwegian MODY Registry and the Norwegian Childhood Diabetes Registry: Clinical Insights and Prevalence Informed by Genetic and Functional Evaluation.Semantic proximity Read ↗

Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.