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Article

Integrated Computational Analysis Reveals Structurally Destabilizing Missense Variants in the PDX1 Transcription Factor.

Genes - 27 Feb 2026

Ahmed Elsadig Mohamed

Abstract excerpt

BACKGROUND/OBJECTIVE: Pancreatic and duodenal homeobox 1 (PDX1) is a key transcription factor required for pancreatic development and maintenance of β-cell function. Genetic variants in PDX1 have been associated with monogenic forms of diabetes, including maturity-onset diabetes of the young type 4 (MODY4). However, the func-tional consequences of many reported non-synonymous single-nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 41898807
DOI: 10.3390/genes17030273
PMCID: PMC13026271

Genes

PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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