Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms

21 Oct 2022

Abstract excerpt

BACKGROUND: Ligation of CD28 with ligands such as CD80 or CD86 provides a critical second signal alongside antigen presentation by class II major histocompatibility complex expressed on antigen-presenting cells through the T cell antigen receptor for naïve T cell activation. A number of studies suggested that CD28 plays an important role in the pathogenesis of various human diseases. Recent genome-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver Diseases and Immunity
Share to Systemic Lupus Erythematosus Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36271469
DOI: 10.1186/s40246-022-00419-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoformsPMID 36271469Read ↗

rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases.Semantic proximity Read ↗

Low-usage splice junctions underpin immune-mediated disease riskSemantic proximity Read ↗

Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency.Semantic proximity Read ↗

Predicting the functional consequences of genetic variants in co-stimulatory ligand B7-1 using in-silico approaches.Semantic proximity Read ↗

Characterising the gene regulatory landscape of CD4+ T cellsSemantic proximity Read ↗

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.Semantic proximity Read ↗

Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern.Semantic proximity Read ↗

Identification of Three Alternatively Spliced Variants of Human CD28 mRNASemantic proximity Read ↗

Five functional polymorphisms of B7/CD28 co-signaling molecules alter susceptibility to colorectal cancer.Semantic proximity Read ↗

Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cellsSemantic proximity Read ↗

CD28 Genetic Variants Increase Susceptibility to Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Case Control Study.Semantic proximity Read ↗

The Role of the CD28 Family Receptors in T-Cell ImmunomodulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.