Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.

doi:10.1038/s41598-017-07967-2

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Article

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.

Scientific reports - 9 Aug 2017

Liaskou Evaggelia, Jeffery Louisa, Chanouzas Dimitrios, Soskic Blagoje, Seldin Michael F, Harper Lorraine, Sansom David, Hirschfield Gideon M

Abstract excerpt

The CD28 locus is associated with susceptibility to a variety of autoimmune and immune-mediated inflammatory diseases including primary sclerosing cholangitis (PSC). Previously, we linked the CD28 pathway in PSC disease pathology and found that vitamin D could maintain CD28 expression. Here, we assessed whether the PSC-associated CD28 risk variant A (rs7426056) affects CD28 expression and T cell function in...

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Identifiers

PMID: 28794437
DOI: 10.1038/s41598-017-07967-2
PMCID: PMC5550460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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