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Article

The effects of altered DNA damage repair genes on mutational processes and immune cell infiltration in esophageal squamous cell carcinoma.

Cancer medicine - 1 Apr 2023

Yuan Huangbo, Qing Tao, Zhu Sibo, Yang Xiaorong, Wu Weicheng, Xu Kelin, Chen Hui, Jiang Yanfeng, Zhu Chengkai, Yuan Ziyu, Zhang Tiejun, Jin Li, Suo Chen, Lu Ming, Chen Xingdong, Ye Weimin

Abstract excerpt

BACKGROUND: Defects in DNA damage repair (DDR) pathways lead to genomic instability and oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC), but the effects of DDR alterations on mutational processes and tumor immune microenvironment in ECSS remain unclear. METHODS: Whole-exome and transcriptome sequencing data of 45 ESCC samples from Taizhou, China, were used to identify genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36708047
DOI: 10.1002/cam4.5663
PMCID: PMC10166979

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