Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ancestry-specific high-risk gene variant profiling unmasks diabetes-associated genes.

Human molecular genetics - 8 Apr 2024

Zhang Jianhua, Chen Weiping, Chen Guanjie, Flannick Jason, Fikse Emma, Smerin Glenda, Degner Katherine, Yang Yanqin, Xu Catherine, Li Yulong, Hanover John A, Simonds William F

Abstract excerpt

How ancestry-associated genetic variance affects disparities in the risk of polygenic diseases and influences the identification of disease-associated genes warrants a deeper understanding. We hypothesized that the discovery of genes associated with polygenic diseases may be limited by the overreliance on single-nucleotide polymorphism (SNP)-based genomic investigation, as most significant variants identified in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Obesity

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 36255737
DOI: 10.1093/hmg/ddac255
PMCID: PMC11000659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ancestry-specific high-risk gene variant profiling unmasks diabetes-associated genes.PMID 36255737Read ↗

The trans-ancestral genomic architecture of glycemic traits.Semantic proximity Read ↗

Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations.Semantic proximity Read ↗

Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complicationsSemantic proximity Read ↗

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translationSemantic proximity Read ↗

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.Semantic proximity Read ↗

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci.Semantic proximity Read ↗

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical HeterogeneitySemantic proximity Read ↗

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.Semantic proximity Read ↗

Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk predictionSemantic proximity Read ↗

Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical Activity and Incident Type 2 DiabetesSemantic proximity Read ↗

Multi-trait GWAS for diverse ancestries: mapping the knowledge gap.Semantic proximity Read ↗

Ancestry-Stratified Transcriptome-Wide Association Study Reveals Tissue-Specific Mechanisms of Type 2 Diabetes HeterogeneitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.