Article
High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.
Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2015
Pyatigorskaya Nadya, Sharman Michael, Corvol Jean-Christophe, Valabregue Romain, Yahia-Cherif Lydia, Poupon Fabrice, Cormier-Dequaire Florence, Siebner Hartwig, Klebe Stephan, Vidailhet Marie, Brice Alexis, Lehéricy Stephane
Abstract excerpt
OBJECTIVES: The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson's disease (PD), using R2* relaxometry rate. METHODS: Twenty subjects with genetic PD (four symptomatic and two asymptomatic Parkin subjects, nine symptomatic and five asymptomatic LRRK2 subjects) were compared...
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