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Article

Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.

Cancer science - 1 May 2013

Ogi Sayaka, Fujita Hideaki, Kashihara Masaki, Yamamoto Chizuko, Sonoda Kahori, Okamoto Isamu, Nakagawa Kazuhiko, Ohdo Shigehiro, Tanaka Yoshitaka, Kuwano Michihiko, Ono Mayumi

Abstract excerpt

The sorting nexin (SNX) family is a diverse group of cytoplasmic and membrane-associated proteins that are involved in membrane-trafficking steps within the endocytotic network. SNX1 and SNX2 are components of the mammalian retromer complex and they also play critical roles in the membrane trafficking of growth factor receptors including epidermal growth factor receptor (EGFR) and c-Met. The human lung cancer...

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Identifiers

PMID: 23360489
DOI: 10.1111/cas.12117
PMCID: PMC7657160

Genes

EGFR
SNX2
SNX1

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Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.PMID 23360489Read ↗

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