Article
Genetic susceptibility loci for Chlamydia trachomatis endometrial infection influence expression of genes involved in T cell function, tryptophan metabolism and epithelial integrity.
Frontiers in immunology - 1 Jan 2022
Zhong Wujuan, Kollipara Avinash, Liu Yutong, Wang Yuhan, O'Connell Catherine M, Poston Taylor B, Yount Kacy, Wiesenfeld Harold C, Hillier Sharon L, Li Yun, Darville Toni, Zheng Xiaojing
Abstract excerpt
Objectives: Identify genetic loci of enhanced susceptibility to Chlamydial trachomatis (Ct) upper genital tract infection in women. Methods: We performed an integrated analysis of DNA genotypes and blood-derived mRNA profiles from 200 Ct-exposed women to identify expression quantitative trait loci (eQTL) and determine their association with endometrial chlamydial infection using a mediation test. We further...
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