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Article

Body-First Subtype of Parkinson's Disease with Probable REM-Sleep Behavior Disorder Is Associated with Non-Motor Dominant Phenotype.

Journal of Parkinson's disease - 1 Jan 2022

Pavelka Lukas, Rauschenberger Armin, Landoulsi Zied, Pachchek Sinthuja, Marques Taina, Gomes Clarissa P C, Glaab Enrico, May Patrick, Krüger Rejko

Abstract excerpt

BACKGROUND: The hypothesis of body-first vs. brain-first subtype of PD has been proposed with REM-Sleep behavior disorder (RBD) defining the former. The body-first PD presumes an involvement of the brainstem in the pathogenic process with higher burden of autonomic dysfunction. OBJECTIVE: To identify distinctive clinical subtypes of idiopathic Parkinson's disease (iPD) in line with the formerly proposed concept...

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Identifiers

PMID: 36245388
DOI: 10.3233/JPD-223511
PMCID: PMC9837682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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