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Article

Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes.

The Journal of clinical investigation - 1 Jun 2020

Liu Yan, Lin Haiyan, Jiang Lin, Shang Qingsen, Yin Lei, Lin Jiandie D, Wu Wen-Shu, Rui Liangyou

Abstract excerpt

De novo lipogenesis is tightly regulated by insulin and nutritional signals to maintain metabolic homeostasis. Excessive lipogenesis induces lipotoxicity, leading to nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Genetic lipogenic programs have been extensively investigated, but epigenetic regulation of lipogenesis is poorly understood. Here, we identified Slug as an important epigenetic regulator...

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Share to Diabetes Mellitus, Type 2
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Hepatocytes

Share to Histone Demethylases

Share to Lipogenesis

Share to Non-alcoholic Fatty Liver Disease

Share to Snail Family Transcription Factors

Source

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Identifiers

PMID: 32365055
DOI: 10.1172/JCI128073
PMCID: PMC7260003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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