Somatic genomic mosaicism in the brain: Identified mutations provide challenges and opportunities for the clinic.

Abstract excerpt

Recent work by Bae et al.1 represents a major next-generation sequencing effort to identify somatic genomic mosaicism in normal and diseased human brains. Some samples displayed age-associated hypermutability, and the general possibility that somatic mutations can drive brain disease has implications for new therapeutic strategies, disease staging, biomarkers, and cohort selection for clinical trials.

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