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Article

Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain.

Cancer discovery - 1 Jan 2022

Ganz Javier, Maury Eduardo A, Becerra Basheer, Bizzotto Sara, Doan Ryan N, Kenny Connor J, Shin Taehwan, Kim Junho, Zhou Zinan, Ligon Keith L, Lee Eunjung Alice, Walsh Christopher A

Abstract excerpt

Although oncogenic mutations have been found in nondiseased, proliferative nonneural tissues, their prevalence in the human brain is unknown. Targeted sequencing of genes implicated in brain tumors in 418 samples derived from 110 individuals of varying ages, without tumor diagnoses, detected oncogenic somatic single-nucleotide variants (sSNV) in 5.4% of the brains, including IDH1 R132H. These mutations were...

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Identifiers

PMID: 34389641
DOI: 10.1158/2159-8290.CD-21-0245
PMCID: PMC8758513

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