Article
APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis.
Immunity - 9 Nov 2021
Wu Junnan, Ma Ziyuan, Raman Archana, Beckerman Pazit, Dhillon Poonam, Mukhi Dhanunjay, Palmer Matthew, Chen Hua Chang, Cohen Cassiane Robinson, Dunn Thomas, Reilly John, Meyer Nuala, Shashaty Michael, Arany Zoltan, Haskó György, Laudanski Krzysztof, Hung Adriana, Susztak Katalin
Abstract excerpt
The incidence and severity of sepsis is higher among individuals of African versus European ancestry. We found that genetic risk variants (RVs) in the trypanolytic factor apolipoprotein L1 (APOL1), present only in individuals of African ancestry, were associated with increased sepsis incidence and severity. Serum APOL1 levels correlated with sepsis and COVID-19 severity, and single-cell sequencing in human...
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